|
KMID : 1189420120250010033
|
|
Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2012 Volume.25 No. 1 p.33 ~ p.54
|
|
|
A Comparative Study on the Effects of Saengmaeksan and Saengmaeksan-gamibang on Atopic Dermatitis in NC/Nga mouse
|
|
Moon Hyo
Hwang Choong-Yeon
Hong Seok-Hoon
Hong Chul-Hee
Kim Nam-Kwen
Jo Ga-Won
Lim Kyu-Sang
|
|
|
Abstract
|
|
|
Objective: This study was carried out to compare Saengmaeksan-gamibang(SG) to Saengmaeksan(SM) on the efficacy of moisturization, skin whitening, anti-inflammation, and anti-allergy in atopic dematitis using NC/Nga mice model.
Methods: We assessed the effects of SG and SM on tyrosinase, filaggrin, serine-palmitoyl transferase(SPT), COX-2, AP-1 in vitro, on IgE, IL-4, IL-5, IL-6, IgM, IgG1, IFN- in vivo with NC/Nga mice.
Results: 1. SG increased the tyrosinase inhibition activity and the levels of filaggrin and SPT, decreasing the level of COX-2. 2. On the other hand, SM decreased the tyrosinase inhibition activity and the levels of filaggrin and SPT, increasing the level of COX-2. 3. Serum IgE, IL-4, 5, 6, IgM, and IgG1 were decreased in both SG group and SM group compared to the control group. The decrease degree in these factors was higher in SG than in SM. 4. Serum IFN- was increased in both SG group and SM group compared to the control group. The increase degree in IFN- was higher in SG than in SM.
Conclusion: As the result of the above experiments, it was proved that SG has the moisturization, skin whitening, anti-inflammation, and anti-allergy effects, which are greater than those of SM, and provides the significant efficacy on atopic dermatitis treatment.
|
|
|
KEYWORD
|
|
|
Saengmaeksan-gamibang, Saengmaeksan, Moisturization, Skin whitening, Anti-inflammation, Anti-allergy, Atopic dermatitis, NC/Nga mice
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|